Antiprogestins
reduce both estrogen and progesterone receptors. Gestrinone
is the standard agent, and may be comparable to GnRH
agonists in reducing pain plus result in fewer menopausal
symptoms. Mifepristone, is also a antiprogestin. In
a six-month study, mifepristone improved symptoms and
reduced endometrial implants without causing menopausal
side effects. Caution, however, this product is known
as the "abortion pill" and can induce a miscarriage
because its antiprogestin effects.
Effects:
• Gestrinone includes male hormone symptoms, to
include acne, and possibly the development of high cholesterol
levels.
Oral Contraceptives
• Generally directed toward stabilizing the production
of hormones (estrogen and progesterone to stimulate
endometrial growth. It has been found that fluctuating
levels of estrogen and progestin stimulate the growth
of endometriosis. Prevents the release of the egg from
the ovary (ovulation). Decreases the amount of blood
loss during the menstrual period. Decreases backward
menstrual period flow into the fallopian tubes and out
into the abdominal cavity (retrograde menstruation).
Stops menstrual periods for long periods of time when
taken over time. Some examples are: estrogen/progestin
combination pills (birth control pills) (Brevicon, Demulen,
Levlen, Levora, Lo/Ovral, Modicon, Nelova, Nelova 10/11,
Nordette, Norethin 1/35E, Norethin 1/50M, Norinyl, Ortho-Novum,
Ovcon, Tri-Levlen, Tri-Norinyl, Triphasil) progestin-only
pills (Micronor, Nor-Q.D., Ovrette)
Effects:
• Painful periods (dysmenorrhea) usually will
return if oral contraceptives are stopped.
• The risk of serious side effects is increased
in Menstrual periods usually are less painful with lighter
flows.
• Young women with very painful menstrual periods
and minimal to mild endometriosis have reported improvement
using a continuous 15-week birth control pill regimen
program.
• Continuous treatment can be used for up to 1
year.
Caution: Oral contraceptives are not recommended if
one has uncontrolled high blood pressure, liver disease,
history of blood clots in a vein (deep vein thrombosis)
or lung (pulmonary embolus), history of stroke nor if
you are over the age of 35 with Diabetes or if you smoke.
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